Sometimes can't respond to cascade
I was playing against Sliver cascade in historic brawl with enough mana open to play Restoration Angel to respond to something my opponent did. My opponent cascaded into a Lightning Bolt, targeting one of my creatures. The game did not give me an opportunity to respond to the Lightning Bolt, and resolved the whole stack without giving me a chance to play.
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StrBean#49384 commented
Same here.
Bloodbraid Elf -> Inquisition of Kozilek.
No nonland permanents but the elf on the battlefield.
Only targetable card in my hand was Orcish Bowmasters, and I had 3 open black to pay for it.
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Harwin#75212 commented
Happened to me as well. Opponent play Imoti, cascaded into Deadly Derision, and I was unable to activate Raf Capashen, Weatherlight Stalwart to pump my creatures before opponent killed Raf.
I would have lost the game anyway (they had more removal that didn't count damage) but still seems bad.