Ancient One won't let you choose targets
When using The Ancient One's activated ability on Arena, it milled me by default rather than letting me mill my opponent. I double checked that there was no effect that stopped me from targeting my opponent.
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VirtualWork#62221
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ilovebraisedmeats#57802 commented
If your opponent had hexproof or protection from something like The One Ring, that would cause the game to automatically choose yourself. I'm guessing this was the case.