When playing with Nykthos, Shrine to Nyx (currently in Mono Green Devotion), There are times on my turn (during main phase) where I've just cast a spell (with Nykthos still untapped and other land to active it) and in response my opponent will cast a removal spell that removes an object that was giving me devotion for Nykthos. However, as I had no instants/flash cards in hand, or no abilities I could activate (with the exception of Nykthos, play instantly passes through to my object being destroyed and the devotion gone. If this was being played in paper before the object is destroyed I could activate Nykthos and float the mana for a later spell.
I understand that I could run the game entirely in Full Control, but that slows down the game immensely, and even though I sometimes manage to hit the Control button as I notice my opponent casting a removal spell it does not seem to be fast enough before my opponents spell resolves and I lose my devotion.
This has caused me to lose games and matches that I may not have otherwise if the game was being played in paper.