Game Crashes and Replay Begins When with Many Triggers on the Stack from a Wheel
This issue has occurred multiple times with various cards:
Nekusar the Mindrazer
The Locust God
Xyris, the Writhing Storm
On multiple occasions, placing multiple triggers onto the stack from a wheel effect such as Megirm, Lilliana's Caress, Waste Not, etc or the afformentioned creatures, the game client crashes and a replay of the game begins.
Most recently it was a crash from Xyris and Purphoros on the field, followed by a Time Reversal. This led to my opponents drawing 7 cards and 21 snake tokens being generated, with Purphoros triggering after ever snake ETBs. The game crashed after about 12 of the tokens had ETB'd.

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PBagel#10031 commented
Yeah, I've had this happen a whole bunch of times. I wish it would get fixed.
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Mutrol#29195 commented
This issue happened to me twice during this weekend, with different decks. System crash and game reboot and play itself. Happened 5 times during my experience with mtgo.
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ThaTimeWarp#88029 commented
Another bump. I have experienced this all to often while playing my Xyris deck.
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mindtap#42783 commented
Bumps to this. I get crash to replay frequently when trying to play 4-player Commander w/ Nekusar... so much so, I have had to stop playing it.