Mr. Neg Bug
I was playing Mister Negative Commander and after moving it back to my command zone and replaying it on MTG Arena; it did not trigger the switch life totals ability or even prompt me
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programalice#04722
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Rezzahan#77802
commented
Which means, you could not legally target your opponent, and the trigger was removed from the stack right away. This is usually due to your opponent having hexproof.