Sheoldred not properly giving priority during upkeep if you have another "on draw" trigger like Teferi
So normally you could kill the Sheoldred with an instant spell during upkeep to avoid the 2 damage and you generally do get the option to do this.
But when I had Teferi in play who also has a trigger when I draw a card I was forced to lose the 2 life from Sheoldred even when I killed it with an instant during upkeep.
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lollifant#12235
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